Download Blood and Bone Marrow Pathology (2nd Edition) by Anna Porwit, Jeffrey McCullough, Wendy N. Erber PDF
By Anna Porwit, Jeffrey McCullough, Wendy N. Erber
Already a regular reference paintings within the box, the recent version of Blood and Bone Marrow Pathology contains the most recent WHO type schemes and the newest ancillary diagnostic concepts in immunohistochemistry and molecular biology that allows you to supply a complete, good balanced and authoritative advisor to the translation and prognosis of neoplastic and non-neoplastic ailments of blood and bone marrow. The textual content is lavishly illustrated with prime quality color photos that exhibit the proper pathological,features and immunohistochemical and molecular markers. The textual content contains a well-organized procedure that includes functional information and clues to assist stay away from pitfalls and to make sure optimum diagnosis
Chapters were completely rewritten and a few new chapters were further specially on myeloid malignancies, in accordance with the WHO 2008 Classification
All chapters were revised to include new points of molecular biology and up-to-date bearing on stream cytometry diagnostics
Greater emphasis on functional diagnostic elements for all disorders
Brand new editorial and contributing writer team.
Full on-line textual content via professional seek advice. complete downloadable picture Bank
Already a typical reference paintings within the box, the recent variation of Blood and Bone Marrow Pathology contains the most recent WHO class schemes and the most recent ancillary diagnostic concepts in immunohistochemistry and molecular biology to be able to supply a accomplished, good balanced and authoritative consultant to the translation and analysis of neoplastic and non-neoplastic ailments of blood and bone marrow. The textual content is lavishly illustrated with prime quality color photos that display the appropriate pathological,features and immunohistochemical and molecular markers. The textual content incorporates a well-organized process that includes sensible counsel and clues to aid keep away from pitfalls and to make sure optimum prognosis
Read or Download Blood and Bone Marrow Pathology (2nd Edition) PDF
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Additional info for Blood and Bone Marrow Pathology (2nd Edition)
Example text
During T-lymphopoiesis in the thymus, the thymus-seeding progenitor (TSP) matures sequentially from early thymic progenitors, through transitional stages to mature T-lymphocytes. During the early stages of T-cell ontogeny rearrangement of the T-cell receptor (TCR) genes occurs in the sequence δ, γ, β and then α. 4 Maturation of T-cells in normal bone marrow and thymus9,41,55 CLP TSP ETP Pre-T Common thymocyte Mature thymocyte T-lymphocyte BM Thymus CD34 + + + + − − − TdT − − + + + + − CD1a − − − + + − − iTCRβ − − − − + + + cCD3ε − − +/− + + + + CD2 − − +/− + + + + sCD3 − − − − − + + CD5 − − +/− + + + + CD7 + + + + + + + CD4 − − − − + +/− +/− CD8 − − − − + +/− +/− CD45RA + + + − − − − CD45RO − − − − +/− + + DJβ − − + + + + + V- DJβ − − − − + + + V-Jα − − − − − + + Blood CLP, common lymphoid progenitor; ETP, early T-cell precursor; TSP, thymus-seeding progenitor.
Between 10 and 14 years, the hemopoietic cells in the middle of the shafts of the long bones become virtually completely replaced by fat cells. Subsequently, these zones of non-hemopoietic yellow marrow spread proximally and distally. Distal spread is the more rapid and by about the 25th year the only regions of the long bones that contain red, hemopoietic marrow are the proximal shafts of the femora and humeri. Other sites Normal bone marrow cells: development and cytology Neutrophil CD34+ Lin − CD34+ Lin− Basophil GM-C SF Monoblast Monocyte Erythroblast Erythrocyte Megakaryoblast Platelets cKIT+ CD34+ Lin − HSC EPO MEP cKIT+ CD38− 7 IL- -3 T FL Lin − Eosinophil GMP cKIT+ CD38+ CD34+ Lin− CMP Myeloblast F G-CS TPO CD7+ CD34+ h-1 Notc CLP CD45RA+ T-cell P IL-7 TSP Thymus T-Lymphocyte TdT+ PAX 5 B-cell P IL-4 Early B B-Lymphocyte CD10+ Stem cell Committed progenitor cells (Bone marrow) Differentiated cells (PB) Fig.
The blood monocytes leave the circulation after 20–40 hours and transform into tissue macrophages. These are present in the BM, as well as other tissues, where they have a role in erythropoiesis and phagocytosis of cell debris (see below). g. by shedding of alveolar macrophages), balanced by the formation of new macrophages from blood monocytes and to a small extent from the division of some existing macrophages. The system of cells concerned with macrophage production is called the mononuclear phagocyte system.