Download Cancer Drug Resistance (Cancer Drug Discovery and by Beverly A. Teicher PDF
By Beverly A. Teicher
Major specialists summarize and synthesize the most recent discoveries about the alterations that take place in tumor cells as they increase resistance to anticancer medicines, and recommend new ways to fighting and overcoming it. The authors evaluate physiological resistance dependent upon tumor structure, mobile resistance according to drug delivery, epigenetic alterations that neutralize or skip drug cytotoxicity, and genetic alterations that modify drug goal molecules via lowering or removing drug binding and efficacy. Highlights contain new insights into resistance to antiangiogenic remedies, oncogenes and tumor suppressor genes in healing resistance, melanoma stem cells, and the advance of more beneficial treatments. There also are new findings on tumor immune get away mechanisms, gene amplification in drug resistance, the molecular determinants of multidrug resistance, and resistance to taxanes and Herceptin.
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Extra resources for Cancer Drug Resistance (Cancer Drug Discovery and Development)
Wilkinson-Berka JL. Vasoactive factors and diabetic retinopathy: vascular endothelial growth factor, cycoloxygenase-2 and nitric oxide. Curr Pharm Des 2004; 10:3331–3348. 3. Folkman J, Hanahan D. Switch to the angiogenic phenotype during tumorigenesis. Princess Takamatsu Symp 1991; 22:339–347. 4. Semenza GL. Targeting HIF-1 for cancer therapy. Nat Rev Cancer 2003; 3:721–732. 5. Rak J, Mitsuhashi Y, Bayko L, et al. Mutant ras oncogenes upregulate VEGF/VPF expression: implications for induction and inhibition of tumor angiogenesis.
TUMOR PH It has long been known that the microenvironment in tumors of both animal and human is acidic as compared with that in normal tissues because of elevated in anaerobic as well as aerobic glycolysis in tumors (1–6). As tumor nodules are formed, neovascularization begins from host venules stimulated by a number of angiogenic factors secreted by the tumor cells as well as adjacent normal cells. The newly formed tumor vascular beds are characterized by a heterogeneous distribution of dilated, irregularly bulged, constricted, twisted, and sharply bent capillary-like blood vessels (14–23).
Three types of ATPdriven H+ pumps have also been identified (57). One of these is an ATPase-linked H+ pump found in some specialized epithelial cells. It has been reported that one of the mechanisms to maintain the cytosolic pH at physiological level is sequestration of cytosolic protons into acidic cellular vesicles such as endoplasmic reticulum, endosomes, and lysosomes. Interestingly, the ATPase-linked H+ pump has been identified in a number of intracellular organelles, indicating that the ATPase-linked H+ pump plays an important role in regulating pH in the vesicles and cytosol.