Download Gynecological Tumors: Recent Progress in Diagnostic by G. Dallenbach-Hellweg (auth.), Nobuaki Sasano MD (eds.) PDF
By G. Dallenbach-Hellweg (auth.), Nobuaki Sasano MD (eds.)
During the prior ten years a variety of new findings were documented within the box of gynecological pathology, specifically in recognize of neoplasms. those findings were generated by means of the applying of lately constructed suggestions of immunology and molecular biology. even though, clinicopathologic examinations· are nonetheless an absolute requirement for the morphologic overview of neoplasms, together with gynecological tumors. The overseas Society of Gynecological Pathologists (ISGYP) has contributed enormously to the development inside gynecological pathology. The ISGYP Nomenclature Committee has promoted the overseas Histological category of Gynecological Tumors lower than the auspices of the W orid health and wellbeing association. a brand new variation of the type of tumors and tumor-like stipulations of trophoblastic ailment, uterine corpus, cervix, vagina, and vulva is at the moment in press. A moment quantity masking the ovaries, fallopian tubes, wide ligament, and feminine peritoneum could be released later. association of medical symposia and seminars has additionally been a tremendous task of the ISGYP. the current editor geared up and chaired a symposium entitled "Recent development in Diagnostic Pathology of Gynecological Tumors" held in Sendai, Japan on eleven April 1986 in shut cooperation with Prof. T. Okagaki, collage of Minnesota clinical university, and less than the joint auspices ofthe ISGYP and the japanese Society of Pathology. the subsequent themes have been mentioned at this symposium: - Immunocytochemistry of gestational trophoblastic ailment (Dr. R.J.
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Extra resources for Gynecological Tumors: Recent Progress in Diagnostic Pathology
Sample text
2 Differential Diagnosis .. 3 Prognosis and Treatment References .. . . . . 35 36 37 37 37 42 44 45 46 46 48 49 50 53 53 54 1 Introduction Mixed miillerian tumors constitute one of the rarer groups of uterine tumors, but have always inspired the interest of clinicians, basic scientists, and pathologists out of proportion to their clinical frequency. They are by definition all composed of an intimate admixture of epithelial and nonepithelial elements, and thus have raised particular questions concerning their histogenesis and pathway of differentiation, as well as the relative contributions of the different elements in determining the natural history, prognosis, and ultimately the treatment of each tumor.
The morphologic changes seen after radiation therapy can be manifold. In general, preexisting glandular patterns become distorted; the nuclei of the carcinoma cells appear pleomorphic and can be greatly enlarged and hyperchromatic due to replication of DNA without cell division. In the cytoplasm, damage to various organelles and destruction of lysosomal membranes may result in vacuolation. Despite these cytologic changes, some of the damaged tumor cells may still be viable and capable of replication.
Mitotic activity in the smooth muscle compartment has been reported as less than 2 mitotic figures per 10 high-power fields, but we have seen a case with a mitotic rate of 9 per 10 high-power fields, which recurred outside the uterus 6 years after hysterectomy (KAKU et al. 1991). Like the other tumors in the mixed miillerian group, APA is a polypoid tumor which presents clinically with abnormal vaginal bleeding. Unlike the other tumors, however, APA occurs in a younger age group (average age 39 years) and tends to be situated in the lower segment or endocervix (MAZUR 1981; YOUNG et al.