Download Handbook of Pathology and Pathophysiology of Cardiovascular by Stephen M. Factor MD, FCAP, ACC, Maria A. Lamberti-Abadi MD, PDF
By Stephen M. Factor MD, FCAP, ACC, Maria A. Lamberti-Abadi MD, Jacobo Abadi MD (auth.)
Autopsy derives from the greek note autopsia, this means that act of seeing with one’s personal eyes. It is still the main target and actual technique to comprehend human. disorder. regrettably, the quantity of autopsies in instructing hospitals has reduced dramatically over the last years. The an important elements that account for this are the hot growth and improvement of recent applied sciences, in particular in diagnostic imaging, immunology, phone biology and genetics. also, the perpetual worry of felony legal responsibility through physicians money owed for its additional decline. therefore, physicians and scientific scholars are engaged in fewer autopsies and aren't reaping the wealthy academic rewards that accompany those examinations. the aim of the post-mortem isn't just to set up the reason for dying, but additionally to figure out the character and process the affliction method. Our target with this booklet is to stress the significance of the autopsy examination and the correlation among pathologic fabric and medical facts via reading real circumstances with problem-based technique. the point of interest of this guide is on heart problems, and while applicable, different sickness different types are incorporated in the event that they influence cardiovascular functionality. The strategy is greater than the standard clinico-pathological correlation. really, we strive to provide the cloth from the viewpoint of the post-mortem desk. We use the medical facts because the preliminary framework and the post-mortem findings to advance a real figuring out of the sickness and the linked pathophysiology of the condition.
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4. 5. 6. 7. 8. 9. Jennings RB, Steenbergen C Jr, Reimer KA. Myocardial ischemia and reperfusion. Monogr Pathol. 1995; 37:47-80. Reimer KA, Vander Heide RS, Jennings RB. Ischemic preconditioning slows ischemic metabolism and limits myocardial infarct size. Ann N Y Acad Sci. 1994; 723:99-115. Jennings RB, Reimer KA. The cell biology of acute myocardial ischemia. Annu Rev Med. 1991; 42:225-46. Reimer KA, Jennings RB. The "wavefront phenomenon" of myocardial ischemic cell death. II. Transmural progression of necrosis within the framework of ischemic bed size (myocardium at risk) and collateral flow.
In the current case, that is precisely what occurred, with a rupture of the posterolateral papillary muscle. This event accounted for the acute mitral regurgitation (new holosystolic 3/6 murmur) followed by rapid development of cardiogenic shock, and respiratory distress due to pulmonary edema. It is not clear why the clinical staff considered the diagnosis of acute aortic dissection with this constellation of findings. An aortic dissection, even if it led to aortic valve insufficiency due to annular disruption, would be associated with a diastolic murmur.
Although based on experimental studies, the concept has been amply verified in humans. It represents the conceptual underpinning for the use of thrombolytic agents, acute catheterization with balloon angioplasty and stenting, and acute coronary artery bypass grafting, during myocardial infarction. In the present case, Mr. S. received the thrombolytic agent TPA, and this led to the development of a SEMI. The reasons for this will become obvious. Acute myocardial infarction occurs with temporal and spatial determinants.