Download Hepatocellular Carcinoma: An Atlas of Its Pathology by Toshiro Nakashima M.D., Masamichi Kojiro M.D. (auth.) PDF
By Toshiro Nakashima M.D., Masamichi Kojiro M.D. (auth.)
Hepatocellular carcinoma is without doubt one of the commonest deadly malignan cies of mankind. as much as a couple of many years in the past it was once regarded upon as a melanoma which aroused normally educational hindrance yet rather little scientific curiosity, simply because its remedy and analysis had a such a lot un favorable outlook. certainly, it used to be generally well-known merely at post-mortem. lately this pessimism has notably replaced and is disappearing to a swiftly accelerating measure. a number of the medical contributions at this transformation in outlook are the results of learn within the a ways East, first, Japan after which progressively extending to its associates. The creation of experimental hepatocarcinogens by means of Yoshida greater than 50 years in the past could have been one of many first very important steps. Hepatocellular motor vehicle cinoma indicates a attribute geographical distribution. With the top occurrence in China, Taiwan, Southeast Asia and sub-Saharan Africa, via southern and jap Europe, whereas typically the occurrence is very low in western and northerly Europe and North and South America.
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Example text
Edmondson-Steiner Classification of HCC Grade I carcinoma. This type of HCC is the most differentiated and consists of tumor cells arranged in a thin trabecular pattern (Fig. 1). Grade I carcinoma is not seen as the sole type in any specimen of this carcinoma but only occurs locally predominantly in grade II. Grade II carcinoma. Although the tumor cells show a marked resemblance to normal hepatic cells, the nuclei are larger and more hyperchromatic than usual. The cytoplasm, however, is abundant and acidophilic.
49a, b. Infiltrative small liver cancer, resected case. 8 em maximum diameter. b The tumor-nontumor boundary is obscure. HE, x I a Fig. 50a, b. Histological features in the same case. a The tumor is highly differentiated, corresponding to Edmondson-Steiner grade I carcinoma. b Occasional glandular structure in the same tumor. HE, x 200 34 Chapter 1 Fig. 51. Same case. Well-differentiated hepatocellular carcinoma proliferating in a solid fashion. HE, x 200 Fig. 52a, b. Same case. Highly differentiated tumor cells are proliferating as they replace the hepatocytes at the tumor-nontumor boundary (arrows).
30. Mixed expansive and infiltrative HCC, multinodular, with liver cirrhosis. Coexistence of well-encapsulated tumors (thick arrow) and infiltrative tumors (thin arrows) Chapter I 24 a b Fig. 31a, b. Mixed expansive and infiltrative HCC, multinodular, with liver cirrhosis. Highly necrotic encapsulated tumor (thick arrow) and infiltrative tumors (thin arrow) , / Fig. 32. Mixed infiltrative and expansive type HCC, multinodular, with liver cirrhosis. Wellencapsulated tumors (thick arrows) and infiltrative tumor spreads (thin arrows) are clearly visible in different liver slices Gross Features and Gross Classification of Hepatocellular Carcinoma 25 a c b d Fig.