Download Integration of Metabolism, Energetics, and Signal by Robert K. Ockner PDF

By Robert K. Ockner

INTEGRATION OF METABOLISM,

ENERGETICS, AND sign TRANSDUCTION

Unifying Foundations in cellphone development and dying, Cancer,

Atherosclerosis, and Alzheimer Disease

ROBERT ok. OCKNER

"Dr. Ockner has written a desirable and unique publication which explores power metabolic hyperlinks to neurodegeneration. he's taking a clean examine metabolic pathways related to interplay among astrocyte and neuron which are very important for mind overall healthiness and will play an important position within the pathogenesis of Alzheimer sickness and different general and pathological phenomena. Dr. Ockner has a exceptional learn profession in fatty acid metabolism and the fatty acid binding proteins and writes with readability upon this under-explored point of the mind in health and wellbeing and ailment. not just is his e-book very important for realizing hyperlinks among systemic and cerebral metabolism in neurodegeneration, yet is a needs to learn for scientists with an curiosity within the connection among metabolic pathways and mind function."

— Dr. Bruce Miller,

Professor of Neurology

Clinical director of the reminiscence and getting older Center

University of California, San Francisco

"I locate this ebook to be a commendable and entire project because it encompasses an assessment of a large region of clinical study. Researchers operating in lipid metabolism to these drawn to mitochondrial energetics and within the mechanisms of sign transduction pathways in melanoma and Alzheimer affliction will take advantage of this book."

—M.A.Q. Siddiqui,

Professor and Chairman of the dept of Anatomy and telephone Biology

SUNY Downstate, Brooklyn, NY

Robert okay. Ockner, M.D. is Professor of medication on the collage of California, San Francisco, and is former Director of the UCSF Liver middle and department of Gastroenterology. He and co-workers before everything pointed out and characterised the cytosolic fatty acid binding proteins. he's a graduate of the Harvard clinical university and accomplished medical and examine education at Boston urban clinic, nationwide Institutes of overall healthiness, and Massachusetts common Hospital.

Cover artwork by way of Sadie McFarlane

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Additional resources for Integration of Metabolism, Energetics, and Signal Transduction: Unifying Foundations in Cell Growth and Death, Cancer, Atherosclerosis, and Alzheimer Disease

Sample text

Nutrient and Energy Metabolism in Cell Proliferation 39 65. L. , Annu Rev Cell Biol 4:155181 (1988). 66. P. Maxwell, G. Dachs, J. , Hypoxia-inducible factor-1 modulates gene expression in solid tumors and influences both angiogenesis and tumor growth, Proc Natl Acad Sci USA 94:8104-8109 (1997). 67. N. Chandel, D. McClintock, C. , J Biol Chem 275:25130-25138 (2000). 68. O. Genbacev, Y. Zhou, J. Ludlow, and S. , Science 277:1669-1672 (1997). 69. E. Greiner, M. Guppy, and K. Brand, Glucose is essential for proliferation and the glycolytic enzyme induction that provokes a transition to glycolytic energy production, J Biol Chem 269:31484-31490 (1994).

In summary, most dividing cells may utilize a range of nutrients but optimal growth depends primarily on increased oxidative phosphorylationmediated ATP biosynthesis. The increase in required to support this is 3. Nutrient and Energy Metabolism in Cell Proliferation 35 fueled largely by glycolysis and the citric acid cycle, reflecting at least in part wg/Wnt-like signaling and transactivation of glycolysis-related genes. : Aerobic Glycolysis, Mitochondrial Respiration, and Oxidative Phosphorylation).

Medema, G. Kops, J. Bos, and B. Burgering, AFX-like Forkhead transcription factors mediate cell-cycle regulation by Ras and PKB through p27kip1, Nature 404:782-788 (2000). 98. H. Tran, A. Brunet, J. , DNA repair pathway stimulated by the forkhead transcription factor FOXO3a through the Gadd45 protein, Science 296:530-534 (2002). 99. Y. Honda, and S. Honda, The daf-2 gene network for longevity regulates oxidative stress resistance and Mn-superoxide dismutase gene expression in Caenorhabditis elegans, FASEB J 13:1385-1393 (1999).

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