Download Molecular Pathology of Lung Diseases by Philip T. Cagle MD (auth.), Dani S. Zander MD, Helmut H. PDF
By Philip T. Cagle MD (auth.), Dani S. Zander MD, Helmut H. Popper MD, Jaishree Jagirdar MD, Abida K. Haque MD, Philip T. Cagle MD, Roberto Barrios MD (eds.)
Molecular Pathology of Lung illnesses, the 1st quantity within the Molecular Pathology Library sequence below the sequence editorship of Philip T. Cagle, MD offers a bridge among scientific pulmonary pathology and simple molecular technology. it's designed to supply a realistic disease-based evaluate that would be valuable to pathologists, pulmonologists, thoracic surgeons and different healthiness care prone drawn to lung disease.
The first sections of the quantity give you the reader with basic innovations, terminology and systems in molecular pathology. the rest of the amount is subdivided into neoplastic and non-neoplastic lung illnesses with specified chapters protecting the present molecular pathology of particular diseases.
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Activated Ras recruits Raf protein–serine/threonine kinase from the cytosol to the plasma membrane where kinases activate Raf. ERK, a member of the MAPK family, is activated by Raf through MAP/ERK kinase (MEK). In turn, the activated ERK phosphorylates and activates multiple other proteins, including other protein kinases. Activated ERK also translocates into the nucleus where it phosphorylates and activates transcription factors including Elk-1. Guanosine triphosphate hydrolysis by GTPase-activating proteins (GAPs) inactivates Ras.