Download New Concepts in Pathology and Treatment of Autoimmune by J.-X. She, S. Eckenrode, Q.-G. Ruan (auth.), C. Pozzilli, P. PDF
By J.-X. She, S. Eckenrode, Q.-G. Ruan (auth.), C. Pozzilli, P. Pozzilli, J.-F. Kapp (eds.)
Autoimmunity, characterised by way of autoreactive lymphocytes and autoantibodies, is the end result of a failure to discriminate among self and non-self, and autoimmune ailments are an expanding probability to humans dwelling within the industrialized nations. Autoimmune issues are treatable, yet now not curable, and sufferers can face incapacity at later phases of the ailment. hence, there's a clinical and financial want for brand spanking new innovations and coverings in autoimmune problems. New innovations and coverings can in basic terms be accomplished by way of an interdisciplinary technique bringing jointly services, applied sciences, and medical adventure. The workshop excited by a number of sclerosis, rheumatoid arthritis and kind I diabetes, and mentioned traditional drug treatments, gene remedy, phone and tissue transplantation treatments, and primary remedies utilizing blood stem cells for reprogramming the sufferers' immune system.
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Adulthood Fig. 1. Type I diabetes is shown as the result of the interaction of three factors : genes, immune-re sponse and environment. Development of the disease at different ages could be related to a predominant "weight" of a single factor in respect to the others . This is demonstrated by the text in capital letters As shown in Fig. I, an interactive combination of three factors (genes, environment, immune response) is required for the induction of type I diabetes. The disease process can be viewed as an iceberg where the tip of the iceberg is represented by the clinical diagnosis preceded by a long latency phase that may last for years before the onset of hyperglycaemia .
This effect may be important for the immunomodulatory activity of type I interferons [27, 79, 83]. The exact mechanism of IFN-~-mediated MHC class II inhibition is not completely understood. It appears that IFN-~ reduces the activity of the class II transactivator CIITA, a factor necessary for IFN-y-induced MHC class II transcription [49]. Apart from the inhibition of MHC class II expression, numerous other immunomodulatory effects of type I interferons have been described. For example, IFN-~ has been shown to upregulate IL-IO expression and secretion by T cells and monocytes [62, 66, 67, 76], 46 R.
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