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By K. H. Hollmann (auth.), K. H. Hollmann, J. de Brux, J. M. Verley (eds.)

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DeOme and Medina (1969) propose a two-step model for mammary tumorigenesis in mice: 1. normal to preneoplasia, and 2. preneoplasia to neoplasia. The reaction is driven toward neoplasia by experimental treatments with certain hormones, mammary tumor virus, and chemical carcinogens. Much experimental data is also consistent with a multistep hypothesis, and both models are compatible with the human system in which the commonest preneoplastic lesions (ALA) appear also to be of lobuloalveolar nature and to include aberrent epithelial cell populations in the terminal ducts and lobules.

1979), this change occurs more frequently in cystadenoma phyllodes. Infarction of fibroadenoma was äescribed by Delarue and Redon (1949), and in three of their cases a carcinoma was present. Other authors have drawn attention to this complication (Wilkinson and Green, 1964 ; Haagensen, 1971 ; ~~ewrnan and Kahn, 1973 ; Majmudar and RosalesQuintana, 1975). The lesion resembles an hemorrhagic infarction surrounded by a sclerous zone. Probably, such an event is related to circulatory trouble or thrombosis can be assimilated to similar changes found in leiomyoma.

6b. S. R. WELLINGS ET AL. Histology of human marnrnary carcinoma ("infiltrating duct carcinoma") growing in host gland free mammary fat pad of nude athymic mouse. Hematoxylin and eosin, 27x. Same at higher magnification. Hematoxylin and eosine, 1 71x. RELATIONSHIP OF HUMAN LESIONS TO PRECANCEROUS MAMMARY LESIONS OF OTHER SPECIES Mouse Inbred mouse strains have been used for decades for experimental mammary studies. High and low marnrnary tumor strains were created by selective breeding practices.

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