Download Pathology of the Aging Human Nervous System, 2nd edition by Serge Duckett, J. C. de la Torre PDF
By Serge Duckett, J. C. de la Torre
This e-book is a concise and useful compendium of neuropathological details for all pros whose accountability it really is to make diagnoses, care, and support aged people troubled with neurological and/or psychiatric issues. The time period neuropathology features a multitude of disciplines together with pathology, histology, genetics, immunology, biochemistry, radiology, and so on. This disciplinary process is mirrored during this booklet. This new version has been thoroughly revised and taken brand new from the 20 th to the twenty first century. uncomplicated neuroscientists have been invited to give a contribution chapters explaining and describing easy medical ideas underlying the neuropathological disciplines. additionally, more information is equipped referring to medic-legal concerns, neuropharmacology, and an inventory of help teams for the aged neurologically or mentally impaired in Brazil, Canada, Germany, the uk, and the united states.
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Extra resources for Pathology of the Aging Human Nervous System, 2nd edition
Example text
23 Altered transcriptional regulation in brain cells with increasing age is suggested by studies of transcription factor activities. 27 Additional data suggest that with increasing age their is a reduced ability of brain cells to cope with (oxidative and metabolic) stress. 28 Levels of catalase activity in brain also decreased with age, wherease levels of glutathione peroxidase activity were unchanged. These age-related changes in antioxidant enzyme activities were paralleled by changes in levels of mRNAs encoding the enzymes.
For example, levels of Par-4 (prostate apoptosis response-4; a leucine zipper and death domain-containing protein originally identified for its role in apoptosis of prostate cells36) mRNA and protein are increased in vulnerable regions (and to a lesser extent in nonvulnerable regions) of AD brain (Fig. 2-2). 37 Recent immunohistochemical analyses of AD brain tis- Figure 2-2. Expression of the apoptosis-related gene Par-4 is increased in brain tissue from patients with Alzheimer's disease (AD). A.
8. Mizutani T, Shimaza H. Neuropathological background of 27 centenarian brains. J Neurol Sci 1992; 108:168. 9. Fayuet G, Hauw JJ, Deleare Y, He Y, Duyckaerts C, et al. Neuropathologie de 20 centenaires. 1. Donnees cliniques. Rev Neurol (Paris) 1994; 150 (1) : 16. 10. Giannakopoulos P, Hof PR, Vallet PG, Giannakopoulos AS, Charnay Y, Bouras C. Quantitative analysis of neuropathologic changes in the cerebral cortex of centenarians. Prog Neuropsychopharmacol Biol Psychiatry 1995; 19 (4):577. 11. Ivan L.