Download Pathology of the Gastro-Intestinal Tract by A A. Johansen (auth.), B. C. Morson (eds.) PDF

By A A. Johansen (auth.), B. C. Morson (eds.)

Immunology, in all its aspects of immunochemistry, humoral immunity, mobile immunity, immunodiagnosis, and immunotherapy, is presently the main swiftly advancing self-discipline of scientific and experimental oncology. yet as in such a lot constructing matters, it's consistently beset with difficulties of method and nomenclature, either one of that are usually intertwined. Indicative of this challenge are our round definitions of antigen and antibody. one other fre­ quent challenge is using the phrases "specific" and "associated" whilst characterizing re­ activities to tumors or the antigenic homes of neoplasms. whilst utilized to melanoma, those phrases are patently very established upon the equipment used to illustrate those characteristics. certainly, the very assorted nature and multitude of varieties of melanoma avoid our making gen­ eralizations or specific statements concerning tumor "specificity. " comparable difficulties come up while one considers that many antigens present in malignant tumors percentage definite houses with embryonic or fetal tissues. First, those observations emphasize a scarcity of actual tumor specificity, for which cause the class of oncofetal antigens has been tested. moment, even if such antigens are really oncofetal relies on the strategy of detection used, and it's been came across that right here too specificity decreases because the antigen assay raises in sen­ sitivity. therefore, even if ingredients should be actually oncofetal in nature nonetheless is still a question of dialogue, and such phrases needs to for this reason be utilized in an operational sense.

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Extra resources for Pathology of the Gastro-Intestinal Tract

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This Fig. 17. A differentiated adenocarcinoma originating from foveolae demonstrating transition form between normal PAS-positive cylindrical epithelium and intestinal epithelium with goblet cells. H&E, x 100 34 usually happens at the point where the foveolar epithelium reaches the surface. During this differentiation they have at an early stage lost their stainability for acid mucus. Under abnormal circumstances this migration may take place without a correspondingly normal differentiation, and the whole foveola will in some cases be covered with immaturelooking cells hardly secreting mucus (Fig.

54 l. Surgical Specimens . . . . . . . . . . . . . . . . . . . 2. Necropsy Studies . . . . . . . . . . . . . . . . . . . 3. Mucosal Changes in Adult Coeliac Disease . . . . . . . . . . . 58 58 IV. Complications ........................................ 1. Malignancy . . . . . . . . . . . . . . . . . . . . 2. Ulceration and Strictures . . . . . . . . . . . . . . . . 3. Mucosal Diaphragms . . . . . . . . . .

Arch. lQ, 348-362 (1940). : A modification of Zimmermann's method for differential staining of gastric mucosa. lb 48-50 (1957). : Diagnostic limits for early gastric cancer by radiography. In: Early Gastric Cancer (T. ), pp. 119-130. Baltimore-London-Tokyo: University Park Press 1971. : Surface carcinoma of the stomach. , 185-193 (1965). , Pack, G. : Neoplasms of the stomach. B. Lippincott Company 1967. : Das Magenfrlihkarzinom in Europa. Dtsch. med. Wschr. 100, 1946-1949 (1975). : Intestinal metaplasia and histogenesis of carcinoma in human stomach.

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