Download Pediatric Neoplasia: Advances in Molecular Pathology and by Navin Pinto MD, Kenan Onel MD, PhD (auth.), Alexander Craig PDF
By Navin Pinto MD, Kenan Onel MD, PhD (auth.), Alexander Craig Mackinnon Jr (eds.)
Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine provides the various significant, suitable advances in molecular pathology which are taking place within the box of pediatric oncology and may function an invaluable evaluate for resident and attending physicians in addition to scientists attracted to figuring out the molecular pathology of pediatric melanoma within the context of medical drugs. Chapters are established upon organ structures, and every is written by way of a professional or pair of specialists of their box with subspecialty education and vast medical adventure. each one bankruptcy describes a variable variety of tumors and contains an summary of the type process and clinicopathological features of every tumor. this is often by way of a dialogue of the molecular pathology appropriate to a particular tumor, together with particular molecular markers of the tumors, equipment used for prognosis or scientific administration, scientific value of the markers, and if applicable, an outline or dialogue of present actions in translational learn or matters that must be addressed sooner or later. Pediatric Neoplasia: Advances in Molecular Pathology and Translational Medicine can be of significant price to pathologists, oncologists, hematologists, inner drugs and pediatric experts, in addition to pharmaceutical execs and translational and scientific researchers.
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Oncology of infancy and childhood. 1st ed. Philadelphia: Saunders, Elsevier; 2009. p. 298. 10. Majhail NS, Lichtin AE. Acute leukemia with a very high leukocyte count: confronting a medical emergency. Cleve Clin J Med. 2004;71(8):633–7. 11. Bennett JM, Catovsky D, Daniel MT, Flandrin G, Galton DA, Gralnick HR, et al. Proposals for the classification of the acute leukaemias. French-American-British (FAB) co-operative group. Br J Haematol. 1976;33(4):451–8. 12. Brunning RD. Classification of acute leukemias.
2). Genetic Abnormalities ALL is genetically heterogeneous. Multivariate analyses in several large clinical studies have clearly established that genetic abnormalities are the most important determinants of response to chemotherapy and outcome in precursor B-ALL [34–43]. Their relevance is likely to increase as targeted therapies are introduced. The genetic abnormalities, which currently have the most significant impact on treatment and management, are t(9;22)(q34;q11)/BCR-ABL1, t(4;11)(q21;q23)/MLL- AFF1, and near haploid/low hypodiploidy, all of which are poor prognostic markers, and to a lesser extent, t(12;21)(p13;q22)/ETV6- RUNX1 and high hyperdiploidy that are favorable prognostic markers [39, 41, 44–46].
4a, b). The t(4;11) demonstrates an age-dependent distribution, and is observed in 50–70% of infant ALL and roughly 5% of pediatric and adult cases. Clinically it is associated with high-risk ALL. Most patients have a CD10−, CD19+ (pro-B) profile with co-expression of myeloid antigens. Breakpoints on MLL gene are dispersed over a wide region, and clustered differently in infant vs. other patients. To date, 104 translocation partners are known of which 64 have been molecularly characterized [69].