Download Robbins & Cotran Pathologic Basis of Disease (9th Edition) by Abul K. Abbas, Vinay Kumar, Jon C. Aster PDF
By Abul K. Abbas, Vinay Kumar, Jon C. Aster
Accountable, present, and entire, Robbins and Cotran Pathologic foundation of sickness, ninth version is the perennially best-selling textual content that you'll use lengthy after your clinical scholar days are at the back of you. A world-class writer staff headed by means of Drs. Vinay Kumar, Abul Abbas, and Jon Aster, supplies the most recent, so much crucial pathology wisdom in a readable, fascinating demeanour, making sure optimum knowing of the newest easy technological know-how and scientific content material. fine quality images and full-color illustrations spotlight new info in molecular biology, affliction classifications, new medicinal drugs and drug remedies, and masses extra.
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Extra info for Robbins & Cotran Pathologic Basis of Disease (9th Edition)
Sample text
Later in the cell cycle, the G2-M restriction point ensures that there has been accurate genetic replication before the cell actually divides. When cells do detect DNA irregularities, checkpoint activation delays cell cycle progression and triggers DNA repair mechanisms. If the genetic derangement is too severe to be repaired, the cells will undergo apoptosis; alternatively, they may enter a nonreplicative state called senescence—primarily through p53dependent mechanisms (see later). Enforcing the cell cycle checkpoints is the job of CDK inhibitors (CDKIs); they accomplish this by modulating CDK-cyclin complex activity.
These are multipotent cells that can differentiate into a variety of stromal cells including chondrocytes (cartilage), osteocytes (bone), adipocytes (fat), and myocytes (muscle). Because these cells can be expanded to large numbers, and can also generate a locally immunosuppressive microenvironment (thus potentially evading rejection), they may represent a ready means of manufacturing the stromal cellular scaffolding for tissue regeneration. cells to achieve the “stem-ness” of ES cells. , fibroblasts), induced pluripotent stem cells (iPS cells) are generated (Fig.
Pathogenesis. Pathogenesis refers to the sequence of cellular, biochemical, and molecular events that follow the exposure of cells or tissues to an injurious agent. The study of pathogenesis remains one of the main domains of pathology. , infection or mutation), it is many steps removed from the expression of the disease. For example, to understand cystic fibrosis it is essential to know not only the defective gene and gene product, but also the biochemical and morphologic events leading to the formation of cysts and fibrosis in the lungs, pancreas, and other organs.