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By William Montagna
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Extra resources for The Structure and Function of Skin
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DEVELOPMENT 41 later it develops over the entire body. When the epidermis forms a stratum eorneum, periderm cells are shed into the amniotic fluid. The epidermis develops asynchronously. For example, in the back and chest, it remains relatively undifferentiated until the fourth fetal month whereas in the eyebrows, lips, and nose it has undergone advanced differentiation even at 3 months. A. The Periderm The periderm is an embryonic or fetal tissue whose structure, function, and fate have been investigated with considerable thoroughness (Breathnach, 1971).
Although cell division in the basal cells of the epidermis is reportedly random, mitotic figures tend to occur more frequently beneath the regions that correspond to the junctions of overlying columns than beneath their central regions. In man, some ordered structure can be seen only where the epidermis is thin. In general, however, human epidermis is thicker than that of most furry animals; hence the ordered structure is not evident. When the intact surface of the skin is viewed with the scanning electron microscope, the cells look remarkably loose (Figs.
The Epidermis Fig. 18. Cytoplasmic details of cells in the stratum spinosum. Desmosomes (D) punctuate the plasma membrane. Clusters of tonofibrils (TB) are scattered throughout the cytoplasm. X 7 0 0 0 . (Courtesy of Dr. D. ) IV. " We do not know whether these fibrous proteins are the substance of the visible intracellular filaments. Analyses of amino acid from isolated fibrillar protein show it to be low in sulfur-containing amino acids like cystine and methionine and rich in proline (Matoltsy, 1965).