Download Insect Nicotinic Acetylcholine Receptors by Steeve Hervé Thany PDF
By Steeve Hervé Thany
The goal of this e-book is to summarize our realizing at the insect nicotinic acetylcholine receptors. This region of study acquired nice impetus from the identity of the 1st subunit sequences for use as neonicotinoid insecticide objective websites. even supposing a publication of this nature provides the main points in simple terms of as a rule released effects, it's was hoping that it will possibly offer an invaluable advisor to the newcomer to the sphere in addition to to show a number of the destiny demanding situations. for instance, we have to verify the appropriate subunit nomenclature of insect nicotinic receptors. This nomenclature varies among species and this ended in a number of the early confusion that persists. we have to be distinctive in determining the subunit composition of local insect nicotinic receptor subtypes, their useful homes and physiological roles.
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Extra info for Insect Nicotinic Acetylcholine Receptors
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Refined structure of the nicotinic acetylcholine receptor at 4A resolution. J Mol Biol 2005; 346(4):967-989. 12. Toyoshima C, Unwin N. Three-dimensional structure of the acetylcholine receptor by cryoelectron microscopy and helical image reconstruction. J Cell Biol 1990; 111(6 Pt 1):2623-2635. 13. Toyoshima C, Unwin N. Ion channel of acetylcholine receptor reconstructed from images of postsynaptic membranes. Nature 1988; 336(6196):247-250. 14. Brejc K, van Dijk WJ, Klaassen RV et al. Crystal structure of an ACh-binding protein reveals the ligand-binding domain of nicotinic receptors.
Ligand-gated ion channels opened by 5-HT in molluscan neurones. Brit J Pharmacol 1996; 119(3):602-608. 69. Kehoe J, McIntosh JM. Two distinct nicotinic receptors, one pharmacologically similar to the vertebrate alpha7-containing receptor, mediate Cl currents in aplysia neurons. J Neurosci 1998; 18(20):8198-8213. 70. Putrenko I, Zakikhani M, Dent JA. A family of acetylcholine-gated chloride channel subunits in Caenorhabditis elegans. J Biol Chem 2005; 280(8):6392-6398. 71. Gisselmann G, Plonka J, Pusch H et al.
A) A cartoon showing the topology of a pLGIC subunit. B) A view from the extracellular side of the Torpedo nAChR looking down through the pore. Each subunit is rendered in a different shade. The M2 transmembrane domains that line the pore are darkened. The star indicates the location of a ligand binding site. C) A side view of B with two subunits removed to reveal the pore. Only part of the intracellular vestibule is resolved. D) One subunit from C (dark blue) overlain with the Gloeobactor violaceus pH-sensitive channel (GLIC, light lavender).